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La Crosse, WI Commercial Property for Sale

La Crosse, WI Commercial Property for Sale (73 Real Estate Listings)

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300 2nd St S, La Crosse

$2,100,000

300 2nd St S, La Crosse

1 Acres 28,700 SqFt Commercial MLS® # 1957016

Radisson Center offers a rare downtown La Crosse redevelopment opportunity with exceptional flexibility and strong repositioning potential. Situated in the heart of the city's vibrant downto...

Coldwell Banker Commercial River ValleyLogo

Active
3055 State Road 16 -, La Crosse

$1,999,999

3055 State Road 16 -, La Crosse

1 Acres 5,000 SqFt Commercial MLS® # 1902550

SELLER FINANCING available with adequate down payment! Prime opportunity to own highly desired real estate right along Highway 16. Own a turnkey building with a rock solid national tenant th...

eXp Realty LLCLogo

Active
530 Lang Dr, La Crosse

$1,900,000

↑ $1,899,998

530 Lang Dr, La Crosse

0 Acres 14 SqFt Commercial MLS® # 1950952

PRIME NORTHSIDE LA CROSSE COMMERCIAL OPPORTUNITY.HIGH TRAFFIC LOCATION, TWO PARCELS, LONG-TERM LEASE IN PLACE.YOUR OPPORTUNITY TO INVEST IN A HIGH VISIBLE, INCOME-PRODUCING COMMERCIAL PROPER...

Cindy Gerke & AssociatesLogo

Active
1411 Rose St, La Crosse

$1,900,000

1411 Rose St, La Crosse

1 Acres 4,818 SqFt Commercial MLS® # 1955978

High visibility 4 bay shop on 1.12 acres along Rose Street, one of La Crosse's busiest corridors. This turnkey property features in floor heat, multiple office spaces, and a clean, modern la...

eXp Realty LLCLogo

Active
529 4th St S 507-521-529, La Crosse

$1,600,000

529 4th St S 507-521-529, La Crosse

1 Acres 5,000 SqFt Commercial MLS® # 1942561

YOUR BUSINESS WILL NOT GET MISSED ON THIS HIGH PROFILE 3/4 ACRE (+/-) DOWNTOWN CORNER IN THRIVING LA CROSSE BUSINESS DISTRICT! PLENTY OF DRIVE BY TRAFFIC/VISIBILITY, CONVENIENT LOCATION FOR...

RE/MAX ResultsLogo

Active
2320 Cunningham St, La Crosse

$1,250,000

2320 Cunningham St, La Crosse

1 Acres 9,100 SqFt Commercial MLS® # 1961422

9100 SF light industrial/flex/commercial property on .86 acre, located in the Interstate Industrial Park in La Crosse, WI. The property has 2 buildings. The first is a 6000 SF block building...

ACRE PropertiesLogo

Active
517 Copeland Ave, La Crosse

$1,200,000

517 Copeland Ave, La Crosse

1 Acres 7,240 SqFt Commercial MLS® # 1780187

Choice commercial building for sale with a choice central location. BUSINESS IS NOT FOR SALE! Building features wide open concepts and will adapt itself to a variety of uses. High ceiling...

Cindy Gerke & AssociatesLogo

Active
423 Main St 425 & 427, La Crosse

$1,150,000

423 Main St 425 & 427, La Crosse

0 Acres 9,000 SqFt Commercial MLS® # 1949898

Own a cornerstone of downtown La Crosse including 423/425 & 427 Main St properties, offered together as a rare mixed-use investment package. Built in 1880, these historic buildings deliver c...

United Country Midwest Lifestyle Properties LLCLogo

Active
324 Main Street, La Crosse

$1,100,000

324 Main Street, La Crosse

0 Acres 4,231 SqFt Commercial MLS® # 7056691

Exceptional location & visibility for your business with parking! Located on the corner of 4th & Main St; DOT reports approximately 10,000 cars a day travel past this location plus significa...

Century 21 AffiliatedRegional Multiple Listing Service of Minnesota Logo

Active
4430 Mormon Coulee Rd, La Crosse

$950,000

4430 Mormon Coulee Rd, La Crosse

1 Acres 2,320 SqFt Commercial MLS® # 1945736

Commercial property with a 3 Bedroom house and 2 car garage located on the southside of La Crosse near Aldi's / Wendy's and Walmart. Corner lot at the stop lights with 4 curb cuts for ingre...

Gerrard-Hoeschler, REALTORSLogo

Active
1613 Chase St, La Crosse

$825,000

↓ $50,000

1613 Chase St, La Crosse

0 Acres 10,712 SqFt Commercial MLS® # 1940868

Nearly 11,000 sq ft of mixed use, versatile and impeccably kept multi-use building is now on the market! This property features two office spaces off of 16th St loaded with high end custom c...

eXp Realty LLCLogo

Active
1101 Lacrosse St, La Crosse

$799,900

↓ $75,100

1101 Lacrosse St, La Crosse

0 Acres 2,200 SqFt Commercial MLS® # 1956084

An exceptional & rare opportunity to own a truly iconic establishment. Chuck's has long been a staple of the community-functioning seamlessly as a dive bar, neighborhood gathering spot, & co...

Realty of America, LLCLogo

Active
820 5th Ave S 822, 826, 828, 421 Winnebago, La Crosse

$750,000

820 5th Ave S 822, 826, 828, 421 Winnebago, La Crosse

0 Acres 1,512 SqFt Commercial MLS® # 1955933

Multiple cash flow streams with bar business and three residential rental units on almost half acre of land. Commercial building on corner of 5th and Winnebago, currently operated as Ye Old ...

RE/MAX ResultsLogo

Active
422 Main St 424, La Crosse

$699,999

↓ $49,001

422 Main St 424, La Crosse

0 Acres 7,400 SqFt Commercial MLS® # 1944606

Discover a rare downtown La Crosse opportunity at 422-424 Main St. Formerly ''The Main'' event venue, this property blends historic character with modern versatility--featuring a large stage...

United Country Midwest Lifestyle Properties LLCLogo

Active
2128-2130 State Road 16 -, La Crosse

$689,000

2128-2130 State Road 16 -, La Crosse

0 Acres 6,298 SqFt Commercial MLS® # 1933103

A commercial location with visibility to 34,000 vehicles per day!! The light industrial zoning offers the possibility for many businesses in the space. The current clinic has several exam ro...

RE/MAX ResultsLogo

Active
1123 3rd St S, La Crosse

$499,900

1123 3rd St S, La Crosse

0 Acres 1,700 SqFt Commercial MLS® # 1951244

This turnkey opportunity features a premier city establishment, with a reputation for excellence. Meticulously maintained and fully operational. The property reflects the deep commitment of ...

Gerrard-Hoeschler, REALTORSLogo

Active
1720 Jackson St, La Crosse

$499,000

↓ $50,000

1720 Jackson St, La Crosse

0 Acres 2,346 SqFt Commercial MLS® # 1952929

Turn-key professional office or behavioral health facility with excellent visibility on Jackson St in La Crosse. This 2,346 SF bi-level building was completely renovated in 2023 and shows in...

Castle Realty, LLCLogo

Active
518 Hagar St 629 Rose Street, La Crosse

$423,500

↓ $26,500

518 Hagar St 629 Rose Street, La Crosse

0 Acres 1,744 SqFt Commercial MLS® # 1931465

Great opportunity to own an established bar. Spacious horseshoe bar with multiple high-top tables for seating. Additional room that has 2 pool tables and gaming machines. Options for pool a...

Bi-State Realty & AppraisalsLogo

La Crosse, WI Real Estate Statistics

Average Price $306K
Lowest Price $0
Highest Price $2.3M
Total Listings 211
Avg. Days On Market 67
Avg. Price/SQFT $832

Property Types (active listings)


As of May 21, 2026 there are 73 active La Crosse, WI commercial real estate listings for sale with an average listing price of $296,130. The highest-priced commercial property listing is $2,100,000, while the lowest priced commercial property can be purchased for $0. La Crosse, WI Commercial properties for sale have an average price of $1,923 per square foot, based on commercial listings with an average of bedrooms, bathrooms, and 7,306 square feet of living space.

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