La Crosse County, WI Commercial Property for Sale (122 Real Estate Listings)

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W2658 State Road 33 -, Greenfield

$5,000,000

W2658 State Road 33 -, Greenfield

8 Acres 110,000 SqFt Commercial MLS® # 1902543

Historic Multi-Unit Healthcare/Assisted Living/Memory Care Facility with Stunning Views.Perched atop one of the region's most beautiful ridges, this four-story historic assisted living facil...

Gerrard-Hoeschler, REALTORSLogo

Active
W7665 Sylvester Rd, Holland

$4,975,000

W7665 Sylvester Rd, Holland

160 Acres 10,000 SqFt Commercial MLS® # 1905593

This is a rare opportunity to own an iconic, successful golf course and restaurant that combines the beauty of Holmen, WI with a thriving business. Whether you're a passionate golfer, an exp...

Coldwell Banker Commercial River ValleyLogo

Active
3340 Kinney Coulee Rd S, Onalaska

$3,699,000

3340 Kinney Coulee Rd S, Onalaska

5 Acres 15,000 SqFt Commercial MLS® # 1969312

Exceptional and rare 5-acre commercial parcel with 425+/- feet of prime I-90 frontage, offering outstanding visibility at interstate elevation! Located near the I-90 & Hwy 16 interchange and...

Edina Realty, Inc.Logo

Active
N5550 County Rd Z, Onalaska

$2,700,000

↓ $300,000

N5550 County Rd Z, Onalaska

2 Acres 17,640 SqFt Commercial MLS® # 1954054

No need to worry about these stunning commercial buildings, completed in early 2025 and ready for your business to move right in. Building 1 features an impressive showroom with office space...

Coulee Real Estate & Property Management LLCLogo

Active
2974 Airport Rd, La Crosse

$2,200,000

2974 Airport Rd, La Crosse

2 Acres 16,080 SqFt Commercial MLS® # 1968027

Available for Sale or Lease! La Crosse's Airport Industrial Park encompasses 95 acres filled with 21 lots including Manufacturing Facilities Operational Hubs and Regional Shipping Faciliti...

Gerrard-Hoeschler, REALTORSLogo

Active
300 2nd St S, La Crosse

$2,100,000

300 2nd St S, La Crosse

1 Acres 28,700 SqFt Commercial MLS® # 1957016

Radisson Center offers a rare downtown La Crosse redevelopment opportunity with exceptional flexibility and strong repositioning potential. Situated in the heart of the city's vibrant downto...

Coldwell Banker Commercial River ValleyLogo

Active
1411 Rose St, La Crosse

$1,900,000

1411 Rose St, La Crosse

1 Acres 4,818 SqFt Commercial MLS® # 1955978

High visibility 4 bay shop on 1.12 acres along Rose Street, one of La Crosse's busiest corridors. This turnkey property features in floor heat, multiple office spaces, and a clean, modern la...

eXp Realty LLCLogo

Active
529 4th St S 507-521-529, La Crosse

$1,600,000

529 4th St S 507-521-529, La Crosse

1 Acres 5,000 SqFt Commercial MLS® # 1942561

YOUR BUSINESS WILL NOT GET MISSED ON THIS HIGH PROFILE 3/4 ACRE (+/-) DOWNTOWN CORNER IN THRIVING LA CROSSE BUSINESS DISTRICT! PLENTY OF DRIVE BY TRAFFIC/VISIBILITY, CONVENIENT LOCATION FOR...

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Active
3055 State Road 16 -, La Crosse

$1,500,000

↓ $499,999

3055 State Road 16 -, La Crosse

1 Acres 5,000 SqFt Commercial MLS® # 1902550

SELLER FINANCING available with adequate down payment! Prime opportunity to own highly desired real estate right along Highway 16. Own a turnkey building with a rock solid national tenant th...

eXp Realty LLCLogo

Active
517 Copeland Ave, La Crosse

$1,200,000

517 Copeland Ave, La Crosse

1 Acres 7,240 SqFt Commercial MLS® # 1780187

Choice commercial building for sale with a choice central location. BUSINESS IS NOT FOR SALE! Building features wide open concepts and will adapt itself to a variety of uses. High ceiling...

Cindy Gerke & AssociatesLogo

Active
423 Main St 425 & 427, La Crosse

$1,150,000

423 Main St 425 & 427, La Crosse

0 Acres 9,000 SqFt Commercial MLS® # 1949898

Own a cornerstone of downtown La Crosse including 423/425 & 427 Main St properties, offered together as a rare mixed-use investment package. Built in 1880, these historic buildings deliver c...

United Country Midwest Lifestyle Properties LLCLogo

Active
324 Main Street, La Crosse

$1,050,000

↓ $50,000

324 Main Street, La Crosse

0 Acres 4,231 SqFt Commercial MLS® # 7056691

Exceptional location & visibility for your business with parking! Located on the corner of 4th & Main St; DOT reports approximately 10,000 cars a day travel past this location plus significa...

Century 21 AffiliatedRegional Multiple Listing Service of Minnesota Logo

Active
3220 Kinney Coulee Rd S, Onalaska

$950,000

3220 Kinney Coulee Rd S, Onalaska

1 Acres 12,000 SqFt Commercial MLS® # 1958117

Unlock the potential of this versatile warehouse/storage building, perfectly suited for a variety of business uses and already configured for a doggy daycare and grooming operation. This pro...

Castle Realty, LLCLogo

Active
234 Leonard St N, West Salem

$895,000

↓ $50,000

234 Leonard St N, West Salem

0 Acres 3,561 SqFt Commercial MLS® # 1951677

Established boutique winery opportunity! This unique offering includes a fully operational winery that manufactures and sells its own wines, serves appetizers, and hosts intimate events for ...

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Active
1613 Chase St, La Crosse

$825,000

↓ $50,000

1613 Chase St, La Crosse

0 Acres 10,712 SqFt Commercial MLS® # 1940868

Nearly 11,000 sq ft of mixed use, versatile and impeccably kept multi-use building is now on the market! This property features two office spaces off of 16th St loaded with high end custom c...

eXp Realty LLCLogo

Pending
601 Mchugh Rd, Holmen

$800,000

601 Mchugh Rd, Holmen

1 Acres 3,846 SqFt Commercial MLS® # 1947075

Presenting a rare opportunity to acquire a meticulously maintained, high-visibility professional center located in fast growing Holmen community. Whether you are looking for a stable additi...

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Active
4430 Mormon Coulee Rd, La Crosse

$800,000

↓ $150,000

4430 Mormon Coulee Rd, La Crosse

1 Acres 2,320 SqFt Commercial MLS® # 1945736

Commercial property with a 3 Bedroom house and 2 car garage located on the southside of La Crosse near Aldi's / Wendy's and Walmart. Corner lot at the stop lights with 4 curb cuts for ingre...

Gerrard-Hoeschler, REALTORSLogo

Active
1101 Lacrosse St, La Crosse

$799,900

↓ $75,100

1101 Lacrosse St, La Crosse

0 Acres 2,200 SqFt Commercial MLS® # 1956084

An exceptional & rare opportunity to own a truly iconic establishment. Chuck's has long been a staple of the community-functioning seamlessly as a dive bar, neighborhood gathering spot, & co...

Realty of America, LLCLogo

La Crosse County, WI Real Estate Statistics

Average Price $325K
Lowest Price $0
Highest Price $7M
Total Listings 889
Avg. Days On Market 78
Avg. Price/SQFT $175

Property Types (active listings)


As of July 21, 2026 there are 122 active La Crosse County, WI commercial real estate listings for sale with an average listing price of $373,539. The highest-priced commercial property listing is $5,000,000, while the lowest priced commercial property can be purchased for $0. La Crosse County, WI Commercial properties for sale have an average price of $72 per square foot, based on commercial listings with an average of bedrooms, bathrooms, and 6,995 square feet of living space.

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